Highest Efficiency Two-Photon Degradable Copolymer for Remote Controlled Release

 

Jason Olejniczak, Jagadis Sankaranarayanan, Mathieu L. Viger, and Adah Almutairi. ACS Macro Lett, 2013, 2, 683–687. DOI: 10.1021/mz400256x

 

Abstract Image

 

To address the scarcity of polymers that degrade upon absorption of near-infrared (NIR) light, we introduce a new polymer containing moieties in its backbone capable of highly efficient NIR-triggered photocleavage. The polymer rapidly undergoes backbone scission in response to both UV–vis and near-infrared light via two-photon absorption, as revealed by gel permeation chromatography. Cleavage of photosensitive groups from the backbone is confirmed by 1H NMR. These polymers were successfully formulated into particles encapsulating a dye that was released upon irradiation with UV–vis and NIR light, as indicated by changes in fluorescence characteristic of increased solvent interaction with cargo. Thus, this new polymer is readily photocleaved by UV–vis and NIR light, giving it a variety of potential applications in photopatterning and on-demand release.