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50th Anniversary Perspective: Metal-Catalyzed Living Radical Polymerization: Discovery and Perspective

Macromolecules - 10 hours 48 min ago

MacromoleculesDOI: 10.1021/acs.macromol.6b02711
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Unbinding Kinetics of a p38 MAP Kinase Type II Inhibitor from Metadynamics Simulations

Journal of the American Chemical SocietyDOI: 10.1021/jacs.6b12950
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Widespread and Indiscriminate Nanosilver Use: Genuine Potential for Microbial Resistance

ACS Nano - Fri, 2017-03-24 12:53

ACS NanoDOI: 10.1021/acsnano.7b01166
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Polyethylene–Poly(ethylene oxide) Hybrid Films Obtained by Crazing and Their Structural Peculiarities

Macromolecules - Fri, 2017-03-24 12:36

MacromoleculesDOI: 10.1021/acs.macromol.6b02512
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ATRP in Water: Kinetic Analysis of Active and Super-Active Catalysts for Enhanced Polymerization Control

Macromolecules - Fri, 2017-03-24 12:36

MacromoleculesDOI: 10.1021/acs.macromol.7b00246
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Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering

Biomaterials - Fri, 2017-03-24 12:10
Publication date: June 2017
Source:Biomaterials, Volume 129

Author(s): Gozde Eke, Naside Mangir, Nesrin Hasirci, Sheila MacNeil, Vasif Hasirci

The aim of this study was to design a dermal substitute containing adipose derived stem cells (ADSC) that can be used to improve the regeneration of skin on difficult wound beds by stimulating rapid neovascularization. This was achieved by first synthesizing methacrylated gelatin (GelMA) and methacrylated hyaluronic acid (HAMA) precursors which could be stored at −80 oC after lyophilisation. Polymer precursors were then dissolved in media (in 15:1 ratio), ADSCs added together with the photoinitiator and crosslinked with 40 s of UV. Hydrogels degraded by 50% over 3 weeks in an in vitro environment. ADSC loaded hydrogels could be easily handled with forceps (compressive modulus was 6 kPa). Transparency of the gel would allow a full field-of-view of a wound site. The hydrogels provided a suitable microenvironment for ADSC proliferation as shown by the filopodia observed in confocal micrographs. In vivo studies demonstrated that stem cell loaded hydrogels increased vascularization by up to 3 fold compared to their cell free counterparts. In conclusion, GelMA/HAMA hydrogels loaded with ADSC showed the desired proliferative and angiogenic properties essential to promote angiogenesis for wound healing and improving survival of tissue engineered skin.
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Actively controlled release of Dexamethasone from neural microelectrodes in a chronic in vivo study

Biomaterials - Fri, 2017-03-24 12:10
Publication date: June 2017
Source:Biomaterials, Volume 129

Author(s): C. Boehler, C. Kleber, N. Martini, Y. Xie, I. Dryg, T. Stieglitz, U.G. Hofmann, M. Asplund

Stable interconnection to neurons in vivo over long time-periods is critical for the success of future advanced neuroelectronic applications. The inevitable foreign body reaction towards implanted materials challenges the stability and an active intervention strategy would be desirable to treat inflammation locally. Here, we investigate whether controlled release of the anti-inflammatory drug Dexamethasone from flexible neural microelectrodes in the rat hippocampus has an impact on probe-tissue integration over 12 weeks of implantation. The drug was stored in a conducting polymer coating (PEDOT/Dex), selectively deposited on the electrode sites of neural probes, and released on weekly basis by applying a cyclic voltammetry signal in three electrode configuration in fully awake animals. Dex-functionalized probes provided stable recordings and impedance characteristics over the entire chronic study. Histological evaluation after 12 weeks of implantation revealed an overall low degree of inflammation around all flexible probes whereas electrodes exposed to active drug release protocols did have neurons closer to the electrode sites compared to controls. The combination of flexible probe technology with anti-inflammatory coatings accordingly offers a promising approach for enabling long-term stable neural interfaces.





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Mechanistic Studies of the Photoinduced Quinone Trimethyl Lock Decaging Process

Journal of the American Chemical SocietyDOI: 10.1021/jacs.6b12007
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A Critical Update on the Synthesis of Carboxylated Polymers of Intrinsic Microporosity (C-PIMs)

Macromolecules - Fri, 2017-03-24 08:04

MacromoleculesDOI: 10.1021/acs.macromol.7b00344
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Mechanisms of Hydrogen-Assisted CO2 Reduction on Nickel

Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b01538
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Solid-Solution Alloying of Immiscible Ru and Cu with Enhanced CO Oxidation Activity

Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b01186
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Expanded Rosarin: A Versatile Fullerene (C60) Receptor

Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b00735
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