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Organic–Inorganic Hybrid Perovskite Nanowire Laser Arrays

ACS Nano - 8 hours 59 min ago

ACS NanoDOI: 10.1021/acsnano.7b01351
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Designing Peptide and Protein Modified Hydrogels: Selecting the Optimal Conjugation Strategy

Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b00513
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Deconvoluting the Bioactivity of Calcium Phosphate-Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties

Advanced Healthcare Materials - 9 hours 56 min ago

Calcium phosphate (CaP)-based ceramics are the most widely applied synthetic biomaterials for repair and regeneration of damaged and diseased bone. CaP bioactivity is regulated by a set of largely intertwined physico-chemical and structural properties, such as the surface microstructure, surface energy, porosity, chemical composition, crystallinity and stiffness. Unravelling the role of each individual property in the interaction between the biomaterial and the biological system is a prerequisite for evolving from a trial-and-error approach to a design-driven approach in the development of new functional biomaterials. This progress report critically reviews various strategies developed to decouple the roles of the individual material properties in the biological performance of CaP ceramics. It furthermore emphasizes on the importance of a comprehensive and adequate material characterization that is needed to enhance our knowledge of the property-function relationship of biomaterials used in bone regeneration, and in regenerative medicine in general.

Calcium phosphate ceramics are the most widely applied synthetic bone graft substitutes. Their biological performance is regulated by a set of largely intertwined material properties. To evolve from a production process-driven to a design-driven development of these biomaterials, it is necessary to unravel the role of each individual property in their interaction with a biological system. For this, strategies to decouple the effects of the individual properties are required.

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Dual Cross-Linked Biofunctional and Self-Healing Networks to Generate User-Defined Modular Gradient Hydrogel Constructs

Advanced Healthcare Materials - 10 hours 2 min ago

Gradient hydrogels have been developed to mimic the spatiotemporal differences of multiple gradient cues in tissues. Current approaches used to generate such hydrogels are restricted to a single gradient shape and distribution. Here, a hydrogel is designed that includes two chemical cross-linking networks, biofunctional, and self-healing networks, enabling the customizable formation of modular gradient hydrogel construct with various gradient distributions and flexible shapes. The biofunctional networks are formed via Michael addition between the acrylates of oxidized acrylated hyaluronic acid (OAHA) and the dithiol of matrix metalloproteinase (MMP)-sensitive cross-linker and RGD peptides. The self-healing networks are formed via dynamic Schiff base reaction between N-carboxyethyl chitosan (CEC) and OAHA, which drives the modular gradient units to self-heal into an integral modular gradient hydrogel. The CEC-OAHA-MMP hydrogel exhibits excellent flowability at 37 °C under shear stress, enabling its injection to generate gradient distributions and shapes. Furthermore, encapsulated sarcoma cells respond to the gradient cues of RGD peptides and MMP-sensitive cross-linkers in the hydrogel. With these superior properties, the dual cross-linked CEC-OAHA-MMP hydrogel holds significant potential for generating customizable gradient hydrogel constructs, to study and guide cellular responses to their microenvironment such as in tumor mimicking, tissue engineering, and stem cell differentiation and morphogenesis.

A user-defined modular gradient hydrogel system is developed by using dual cross-linked biofunctional and self-healing networks. The modular gradient hydrogel construct can be generated with various gradient distributions and flexible shapes as defined by users. The encapsulated cells are responsive to the gradient cues in the hydrogel construct, which holds potential to study cellular responses to their tissue microenvironment.

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Nanocomposites: High-Energy-Density Dielectric Polymer Nanocomposites with Trilayered Architecture (Adv. Funct. Mater. 20/2017)

Advanced Functional Materials - 11 hours 14 min ago

Multilayered polymer nanocomposites with high energy and power densities are described by Chuanxi Xiong, Hong Wang, Qing Wang, and co-workers in article number 1606292. Boron nitride nanosheets dispersed in poly(vinylidene fluoride) (PVDF) matrix provide high breakdown strength for the outer layer, while PVDF with barium strontium titanate nanowires forms a central layer ensuring high dielectric constant of the resulting composites.

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Sensors: Stretchable Capacitive Sensors of Torsion, Strain, and Touch Using Double Helix Liquid Metal Fibers (Adv. Funct. Mater. 20/2017)

Advanced Functional Materials - 11 hours 14 min ago

Scanning electron micrographs of hollow elastic fibers. Injecting the core with liquid metal renders the fibers conductive. As Michael D. Dickey and co-workers present in article number 1605630, two or more fibers twisted together can sense large amounts of torsion due to changes in geometry, and therefore capacitance, between the fibers. Self-capacitance between fingers and the metal in the fibers allows for touch sensing.

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Cancer Therapy: Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer (Adv. Funct. Mater. 20/2017)

Advanced Functional Materials - 11 hours 14 min ago

In article number 1606530, Haijun Yu, Yaping Li, and co-workers present a clinically translatable multi-responsive vesicle to overcome the sequential biological barriers for improved therapy of triple-negative breast cancer (TNBC). The liposomal vesicles display multi-stimuli sensitivity toward enzymes, light, and temperature, and can encapsulate both a hydrophobic drug and a hydrophilic drug, thereby presenting a novel nanoplatform for TNBC combination therapy.

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Anti-Counterfeiting: Lanthanide “Chameleon” Multistage Anti-Counterfeit Materials (Adv. Funct. Mater. 20/2017)

Advanced Functional Materials - 11 hours 14 min ago

In article number 1700258, Anna M. Kaczmarek, Rik Van Deun, and co-workers describe hybrid materials displaying a multi-stage security behavior, where a single material shows both wavelength- and temperature-dependent luminescence properties. The materials consist of mixed lanthanide β-diketonate complexes grafted into the pores of a nano-sized metal organic framework (MOF), which show “chameleon” behavior.

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Bioelectronic Devices: Cell Generator: A Self-Sustaining Biohybrid System Based on Energy Harvesting from Engineered Cardiac Microtissues (Adv. Funct. Mater. 20/2017)

Advanced Functional Materials - 11 hours 14 min ago

In article number 1606169, Peng Shi and co-workers fabricate a bio-hybrid “Cell Generator” by patterning cardiomyocytes on arrays of micro-cantilevers made of piezoelectric materials. Pulsed contraction of the engineered cardiac constructs provides the source of mechanical energy for electricity generation, which is used to power small biomedical devices. This technology provides an innovative perspective of exploiting live biological components for the development of self-sustaining cellular machines.

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Bottom-Up Preparation of Uniform Ultrathin Rhenium Disulfide Nanosheets for Image-Guided Photothermal Radiotherapy

Advanced Functional Materials - Mon, 2017-05-22 23:40

Facile preparation of multifunctional theranostic nanoplatforms with well-controlled morphology and sizes remains an attractive in the area of nanomedicine. Here, a new kind of 2D transition metal dichalcogenide, rhenium disulfide (ReS2) nanosheets, with uniform sizes, strong near-infrared (NIR) light, and strong X-ray attenuation, is successfully synthesized. After surface modification with poly(ethylene glycol) (PEG), the synthesized ReS2-PEG nanosheets are stable in various physiological solutions. In addition to their contrasts in photoacoustic imaging and X-ray computed tomography imaging because of their strong NIR light and X-ray absorptions, respectively, such ReS2-PEG nanosheets can also be tracked under nuclear imaging after chelator-free labeling with radioisotope ions, 99mTc4+. Efficient tumor accumulation of ReS2-PEG nanosheets is then observed after intravenous injection into tumor-bearing mice under triple-modal imaging. The combined in vivo photothermal radiotherapy is further conducted, achieving a remarkable synergistic tumor destruction effect. Finally, no obvious toxicity of ReS2-PEG nanosheets is observed from the treated mice within 30 d. This work suggests that such ultrathin ReS2 nanosheets with well-controlled morphology and uniform sizes may be a promising type of multifunctional theranostic agent for remotely triggered cancer combination therapy.

A one-step bottom-up method is developed to synthesize a new kind of transition metal dichalcogenide (TMDC), rhenium disulfide (ReS2), with well-defined 2D nanosheet morphology and uniform sizes, for multimodal imaging-guided cancer combination therapy.

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A Patterned Graphene/ZnO UV Sensor Driven by Integrated Asymmetric Micro-Supercapacitors on a Liquid Metal Patterned Foldable Paper

Advanced Functional Materials - Mon, 2017-05-22 23:10

A foldable array of patterned graphene/ZnO nanoparticle UV sensor and asymmetric micro-supercapacitors (AMSCs) integrated on a paper substrate with patterned liquid metal interconnections is reported. The resistor type UV sensor based on graphene/ZnO nanoparticles is patterned to be driven by the stored energy of the integrated AMSCs. The AMSC consists of MnO2 nanoball deposited multiwalled carbon nanotubes (MWNTs) and V2O5 wrapped MWNTs as positive and negative electrodes, respectively. As an electrolyte, propylene carbonate-poly(methyl methacrylate)-LiClO4, an organic solvent-based gel, is used. The UV sensor and AMSCs can be easily integrated on a liquid metal, Galinstan, patterned, waterproof mineral paper and show a mechanically stable UV sensing, regardless of repetitive folding cycles. This work demonstrates a novel foldable nanomaterial based sensor system driven by integrated energy storage devices, applicable to future wearable and portable electronics.

A patterned graphene/ZnO UV sensor driven by integrated asymmetric micro-supercapacitors (AMSCs) on a liquid metal patterned foldable substrate is demonstrated. With the stored energy of the AMSCs, the integrated UV sensor is operated stable for 1500 s under deformations of folding.

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