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Modulation of Cell-Cell Interactions for Neural Tissue Engineering: Potential Therapeutic Applications of Cell Adhesion Molecules in Nerve Regeneration

Biomaterials - 19 hours 34 min ago

Publication date: Available online 21 January 2019

Source: Biomaterials

Author(s): Wai Hon Chooi, Sing Yian Chew

Abstract

Neural tissue engineering holds great promise in repairing damaged nerve tissues. However, despite the promising results in regenerating the injured nervous system, tissue engineering approaches are still insufficient to result in full functional recovery in severe nerve damages. Majority of these approaches only focus on growth factors and cell-extracellular matrix (ECM) interactions. As another important component in nerve tissues, the potential of modulating cell-cell interactions as a strategy to promote regeneration has been overlooked. Within the central nervous system, there are considerably more cell-cell communications as compared to cell-ECM interactions, since the ECM only contributes 10 % - 20 % of the total tissue volume. Therefore, modulating cell-cell interactions through cell adhesion molecules (CAMs) such as cadherins, neural cell adhesion molecules (NCAM) and L1, may be a potential alternative to improve nerve regeneration. This paper will begin by reviewing the CAMs that play important roles in neurogenic processes. Specifically, we focused on 3 areas, namely the roles of CAMs in neurite outgrowth and regeneration; remyelination; and neuronal differentiation. Following that, we will discuss existing tissue engineering approaches that utilize CAMs and biomaterials to control nerve regeneration. We will also suggest other potential methods that can deliver CAMs efficiently to injured nerve tissues. Overall, we propose that utilizing CAMs with biomaterials may be a promising therapeutic strategy for nerve regeneration.

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A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy

Biomaterials - Sat, 2019-01-19 03:02

Publication date: Available online 18 January 2019

Source: Biomaterials

Author(s): Yanbing Wang, Zhuo Wang, Caina Xu, Huayu Tian, Xuesi Chen

Abstract

Despite multifunctional nanoparticles using for photothermal therapy can efficiently kill cancer cells, their further application is still hindered by the intrinsic high uptake in the reticuloendothelial system (RES) organs, causing the slow elimination from the body and potential toxicity to the body. Therefore, it is ideal to develop multifunctional nanoparticles which process the ability to effectively accumulate in tumors, while the nanoparticles can be rapidly excreted from the body via renal clearance after effective treatment. Herein, we report the multifunctional nanoparticles (FeTNPs) based on the coordination interaction of phenolic group and metal iron, which are composed of ferric iron, tannic acid (TA) and poly (glutamic acid)-graft-methoxypoly (ethylene glycol) (PLG-g-mPEG). FeTNPs exhibit the following highlighted features: (1) The effective accumulation in the tumor tissue is achieved based on EPR effect. (2) The dual photoacoustic (PA)/magnetic resonance (MR) imaging capacity can provide guidance for the photothermal therapy (PTT). (3) FeTNPs can be dynamically disassembled by deferoxamine mesylate (DFO) to accelerate elimination of the nanoparticles, thus reducing the potential toxicity for the body. The DFO triggered dynamic disassembling strategy may open a new avenue to overcome the dilemma between EPR effect and renal clearance.

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Multifunctional nanoplatforms for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis

Biomaterials - Sat, 2019-01-19 03:02

Publication date: Available online 18 January 2019

Source: Biomaterials

Author(s): Xianxian Yao, Peng Yang, Zhaokui Jin, Qin Jiang, Ranran Guo, Ruihong Xie, Qianjun He, Wuli Yang

Abstract

A multifunctional CO/thermo/chemotherapy nanoplatform is here reported, which is composed of mesoporous carbon nanoparticles (MCN) as near infrared (NIR)-responsive drug carrier, doxorubicin (DOX) as chemotherapeutic drug and triiron dodecacarbonyl (FeCO) as thermosensitive CO prodrug. The nanoplatform could absorb near-infrared (NIR) light and convert it into ample heat to trigger CO release and could also release DOX in the acidic tumor microenvironment. More importantly, the generated CO molecules successfully increase cancer cell sensitivity to chemotherapeutics by the ferroptosis pathway. Subsequently, under the guidance of photoacoustic imaging, the FeCO-DOX@MCN nanoplatform demonstrates high treatment efficacies in vitro and in vivo by combination of chemotherapy, photothermal therapy and gas therapy. This multifunctional platform with excellent antitumor efficacy has great potential in precision cancer therapy.

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Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced <em>in vivo</em> transfection

Biomaterials - Fri, 2019-01-18 02:58

Publication date: Available online 17 January 2019

Source: Biomaterials

Author(s): Naoto Yoshinaga, Satoshi Uchida, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka

Abstract

There has been a progressive interest in the molecular design of polymers and lipids as synthetic carriers for targeting therapeutic mRNA in vivo with the ability to circumvent nuclease attack for treating intractable diseases. Herein, we developed a simple approach to attain one order of magnitude higher nuclease tolerability of mRNA through the formation of polyplex micelles (PMs) by combining ω-cholesteryl (ω-Chol)-poly (ethylene-glycol) (PEG)-polycation block copolymers with mRNA pre-hybridized with cholesterol (Chol)-tethered RNA oligonucleotides (Chol (+)-OligoRNA). Even one or a few short Chol (+)-OligoRNA anchors harboring along the 46-fold longer mRNA strand was sufficient to induce tight mRNA packaging in the PM core, as evidenced by Förster resonance energy transfer (FRET) measurement as well as by a longitudinal relaxation time (T1) measurement using NMR. These results suggest that Chol (+)-OligoRNA on mRNA strand serves as a node to attract ω-Chol moiety of the block copolymers to tighten the mRNA packaging in the PM core. These mRNA loaded PMs showed high tolerability against nuclease attack, and exerted appreciable protein translational activity in cultured cells without any inflammatory responses, achieved by shortening of the length of hybridizing Chol (+)-OligoRNAs to 17 nucleotides. Finally, the Chol (+)-OligoRNA-stabilized PM revealed efficient mRNA introduction into the mouse lungs via intratracheal administration, demonstrating in vivo utility of this formulation.

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[ASAP] NHC-Catalyzed Deamination of Primary Sulfonamides: A Platform for Late-Stage Functionalization

Journal of the American Chemical SocietyDOI: 10.1021/jacs.8b11800
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[ASAP] Radical Approach to Thioester-Containing Polymers

Journal of the American Chemical SocietyDOI: 10.1021/jacs.8b12154
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[ASAP] Ligand-Dependent Colloidal Stability Controls the Growth of Aluminum Nanocrystals

Journal of the American Chemical SocietyDOI: 10.1021/jacs.8b12255
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[ASAP] Guest-Dependent Dynamics in a 3D Covalent Organic Framework

Journal of the American Chemical SocietyDOI: 10.1021/jacs.8b13691
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[ASAP] Lithiation Behavior of Coaxial Hollow Nanocables of Carbon–Silicon Composite

ACS Nano - Thu, 2019-01-17 21:00

ACS NanoDOI: 10.1021/acsnano.8b08962
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[ASAP] Design Principle of Fe–N–C Electrocatalysts: How to Optimize Multimodal Porous Structures?

Journal of the American Chemical SocietyDOI: 10.1021/jacs.8b11129
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