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Fundamental Insights into the Reductive Covalent Cross-Linking of Single-Walled Carbon Nanotubes

Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b12910
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Cathode Dependence of Liquid-Alloy Na–K Anodes

Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b12267
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C–H to C–N Cross-Coupling of Sulfonamides with Olefins

Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b13492
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Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides

Molecular Pharmaceutics - 8 hours 11 min ago

Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.7b01130
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Separation of Xylene Isomers through Multiple Metal Site Interactions in Metal–Organic Frameworks

Journal of the American Chemical SocietyDOI: 10.1021/jacs.7b13825
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Highly Sensitive Bulk Silicon Chemical Sensors with Sub-5 nm Thin Charge Inversion Layers

ACS Nano - 13 hours 49 min ago

ACS NanoDOI: 10.1021/acsnano.8b00580
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π-Conjugated Dithienophosphole Derivatives as High Performance Photoinitiators for 3D Printing Resins

Macromolecules - 14 hours 43 min ago

MacromoleculesDOI: 10.1021/acs.macromol.8b00044
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Antibody-Based Therapeutics: Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation (Adv. Healthcare Mater. 4/2018)

Advanced Healthcare Materials - 17 hours 50 min ago

In article number 1700870, Yoon-Sik Lee and co-workers demonstrate in vivo validation process of candidate antibodies against human colon cancer, using a ratiometric quantification method. The validation is performed on a single mouse and analyzed by multiplexed surface-enhanced resonance Raman scattering (SERRS) with ultrasensitive and near-infrared (NIR)-active SERRS nanoprobes (NIR-SERRS dots).

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Therapeutic Nucleic Acids: Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids (Adv. Healthcare Mater. 4/2018)

Advanced Healthcare Materials - 17 hours 50 min ago

Polymeric materials responsive to endogenous and exogenous stimuli promise to overcome multitude of barriers faced during systemic delivery of therapeutic nucleic acids. In article number 1701070, David Oupický and co-workers survey successful examples of enhanced nucleic acid delivery using polymers that respond to changes in pH, redox state, enzyme levels, hypoxia, reactive oxygen species, light, ultrasound, and hyperthermia.

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Human Tissue Models: Engineering 3D Hydrogels for Personalized In Vitro Human Tissue Models (Adv. Healthcare Mater. 4/2018)

Advanced Healthcare Materials - 17 hours 50 min ago

The use of hydrogel scaffolds for developing in vitro patient-specific tissue and organ models using human-derived cells is a powerful platform for studying the mechanism of disease initiation and progression, screening of potential drug candidates, and ultimately, the regeneration of fully functional tissues and organs. In article number 1701165, Murat Guvendiren and co-workers review the current developments in hydrogel-based in vitro tissue models and fabrication techniques, with particular focus on liver and cancer tissues.

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Bio-inspired redox-cycling antimicrobial film for sustained generation of reactive oxygen species

Biomaterials - 18 hours 41 min ago
Publication date: April 2018
Source:Biomaterials, Volume 162

Author(s): Huan Liu, Xue Qu, Eunkyoung Kim, Miao Lei, Kai Dai, Xiaoli Tan, Miao Xu, Jinyang Li, Yangping Liu, Xiaowen Shi, Peng Li, Gregory F. Payne, Changsheng Liu

Open wounds and burns are prone to infection and there remains considerable interest in developing safe and effective mechanisms to confer antimicrobial activities to wound dressings. We report a biomimetic wound dressing for the in situ and sustained generation of reactive oxygen species (ROS). Specifically, we fabricate a catechol-modified chitosan film that mimics features of the melanin capsule generated during an insect immune response to infection. We use an electrochemical reverse engineering approach to demonstrate that this catechol-chitosan film possesses redox-activities and can be repeatedly oxidized and reduced. In vitro tests demonstrate that this film catalyzes the transfer of electrons from physiological reductant ascorbate to O2 for sustained ROS generation, and confers ascorbate-dependent antimicrobial activities. In vivo antimicrobial experiment with a rat subcutaneous model indicates the catechol-chitosan film at reduced state inhibits the bacterial growth and alleviates the infection of the incisions. Open wound healing tests with a mouse model indicate that the catechol-chitosan film suppresses the bacterial population at the wound site, induces less inflammation and promotes wound healing. We envision this biomimetic approach for the sustained, localized and in situ generation of ROS could provide new opportunities for wound management by protecting against pathogen infection and potentially even enlisting ROS-mediated wound healing mechanisms.
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